14D2I74 - Stem cells and their role in tissue homeostasis and regenerative medicine

Course specification
Course titleStem cells and their role in tissue homeostasis and regenerative medicine
Type of studyPhD academic studies
Lecturer (for classes)
  1. prof. dr Milica Kovačević-Filipović
  2. prof. dr Anita Radovanović
  3. prof. dr Danica Marković
Lecturer/Associate (for practice)
    Lecturer/Associate (for OTC)
      The goalThe aim of the course is that students perceive tissue homeostasis through the prism of dynamic self-renewal and regeneration of tissues and organs. The program should enable students to better understand the different pathological processes such as neoplastic processes, acute and chronic inflammation and degeneration during aging. In addition, this course is an introduction to regenerative medicine.
      The outcomeKnowledge of the regenerative capacity of different tissues and the possibility to apply this knowledge to test stem cells.
      Contents of lecturesStem cells (SC): definition, classification and origin of the different types. The differentiation of cells. Explanation of terms: Totipotent, pluripotent, multipotent and unipotent. Cloning. Embryonic and fetal SC. SC from umbilical cord blood and Wharton jelly. Hematopoietic SC. Angiogenesis. Mesenchymal SC. Osteogenesis. Chondrogenesis. Adipogenesis. SC originating from the endoderm and ectoderm. Tissues with higher and lower regenerative potential: the nervous system, muscle, endothelium, liver. Induced pluripotent SC. Cryopreservation of cells. Clinical application. Tissue engineering. Biomaterials and biocompatibility. The reaction of tissue to biomaterials.
      Contents of exercisesAnalysis of the research results obtained by different techniques.
      1. Vunjak-Novaković G. i Freshney RI. Culture of Cells for Tissue Engineering. Wiley-Liss, 2006 (ISBN -13 978-0-471-62935-1) (Original title)
      2. Tatjana Božić, Pathophysiology of domestic animals, 2012 (ISBN 978-86-6021-051-9)
      3. Bongso A. i Lee EH, Stem Cells – From Bench to Bedside – World Scientific Publishing Co. Pte. Ltd, 2005 (IBN 981-256-126-9) (Original title)
      Number of hours per week during the semester/trimester/year
      LecturesExercisesOTCStudy and ResearchOther classes
      Methods of teachingTheoretical and practical classes, critical discussion.
      Knowledge score (maximum points 100)
      Pre obligationsPointsFinal examPoints
      Activites during lectures10Test paper60
      Practical lessonsOral examination