14D2O01 - Integration of metabolism and organs function

Course specification
Course titleIntegration of metabolism and organs function
Type of studyPhD academic studies
Lecturer (for classes)
  1. prof. dr Ivan Jovanović
  2. prof. dr Danijela Kirovski
  3. prof. dr Miodrag Lazarević
  4. prof. dr Natalija Fratrić
  5. prof. dr Dragan Gvozdić
  6. prof. dr Milica Kovačević-Filipović
  7. prof. dr Sunčica Borozan
  8. prof. dr Jelena Ajtić
Lecturer/Associate (for practice)
    Lecturer/Associate (for OTC)
      The goal- to widen the specific information that students acquired in Biochemistry course; - to enable student to form the complex view of normal metabolic transformations in the organism of healthy animals, and form the basis to understand the changes occurring during the disease; - to enable student to efficiently acquire information in later stages of PhD studies.
      The outcomeAfter a successful conclusion of the course, students should: - have the detailed understanding of the enzymes' molecular structure and mechanisms of enzyme catalysis; - understand the mechanisms, benefits and risk of the oxidative metabolism and anti-oxidative strategies in the body; - detailed understanding of the metabolic processes specific for different tissues; - understand the mechanisms of integration and regulation of metabolic processes occurring in different tissues; - detailed understanding of the specific metabolic patterns in ruminants, birds and fish.
      Contents of lecturesThermodynamics of the biochemical reaction and trans-membrane transport. Mechanisms of the trans-membrane transport. Enzyme kinetics, structure, catalytic site, catalytic strategies. Activation - inhibition. Biological oxidation: oxidative phosphorylation; free radicals and anti-oxidative defense. Regulation of the metabolism: allosteric, covalent, enzyme concentration, cellular compartments, metabolic specialization of tissues. Reminder of the main metabolic pathways, their connections and regulation. Hormonal control of the metabolism. Effect of feeding and fasting on metabolism. Metabolism in tissues: Blood and hematopoietic cells; blood proteins; acute phase proteins; lipoproteins. Skeletal muscles, smooth muscles, myocardium; muscular contractile proteins. Liver. Kidney. Brain. Eye. Bone tissue. Skin. Mammary gland. Metabolism of hormones. Bodily fluids in reproduction. Metabolism in ruminants, birds and fish.
      Contents of exercises-
      1. Mihailović M. Jovanović I. (2008) Biohemija,V izd., Naučna, Beograd. (Original title)
      2. Stojić. V. (2007) Veterinaska fiziologija, Naučna, Beograd. (Original title)
      3. Biochemistry, A Short Course (2010) John L. Tymoczko, Jeremy M. Berg, Lubert Stryer, W. H. Freeman and Company, New York, USA. (Original title)
      4. Fundamentals of Biochemistry, Life at the Molecular Level (2013) Donald Voet, Judith G. Voet, Charlotte W. Pratt, 4th ed., John Wiley & Sons, Inc. (Original title)
      5. Principles of Biochemistry (2012) Laurence A. Moran, H. Robert Horton, K. Gray Scrimgeour, Marc D. Perry. 5th ed., Pearson. (Original title)
      Number of hours per week during the semester/trimester/year
      LecturesExercisesOTCStudy and ResearchOther classes
      Methods of teaching- Theoretical lectures, audio-visual presentations
      Knowledge score (maximum points 100)
      Pre obligationsPointsFinal examPoints
      Activites during lectures10Test paper70
      Practical lessons0Oral examination0