14D2I28 - Drugs action mechanisms

Course specification
Course titleDrugs action mechanisms
Type of studyPhD academic studies
Lecturer (for classes)
  1. prof. dr Saša Trailović
  2. prof. dr Mirjana Milovanović
Lecturer/Associate (for practice)
    Lecturer/Associate (for OTC)
      ConditionEnrolled semester in which the subject is attended.
      The goalWell-known mechanisms of action of the drugs of all pharmacodynamic groups used in veterinary medicine. Make clear and understandable differences in the mechanisms of the therapeutic and side effects of drugs, as well as differences in the mechanisms that exert a antagonisitic or synergistic drug interactions.
      The outcomeAs a result of the course, the student must know the basic principles of the mechanisms by which drugs of different pharmacodynamic groups act. Student should understand the mechanisms of action of drugs and use this knowledge in further scientific work with drugs.
      Contents of lecturesGeneral Part: Introduction to Pharmacodynamics, Subject and Task; Drugs, origin, nature; Introduction of new drugs - preclinical and clinical trials of drugs; Pharmacodynamics, effect of drugs on the organism, types and character of action, place and mechanisms of action of drugs; Receptors, drug-receptor interaction, receptors and transmembrane signal transduction, consequences of receptor drug binding (receptor internalization, agonist-antagonist system), receptor desensitization, receptor regulation; Ion channels as drug sites of action, sodium, calcium, potassium, chloride channels; Enzymes as drug sites; Transport cell systems as a site of action of drugs; Quantitative aspects of drug action: dose-effect ratio, gradual and quantum; Pharmacodynamic models and pharmacodynamic parameters; Tolerance, tachyphylaxis and resistance mechanisms and types; Dosage and dosing of drugs, types of doses, expression of doses; Drug interactions: synergism and antagonism; Drug selectivity, side effects, adverse reactions of genetic origin and pharmacogenetics, allergic reactions; Drug addiction, mechanisms of formation and types of addiction. Special part: Mechanisms of action of drugs acting on different organ systems.
      Contents of exercisesExperimental work in the pharmacodynamic laboratory at the Department of Pharmacology and Toxicology.
      1. 1. Rang H., Maureen M.D., Ritter J.M., Moore P.K. (2006) Farmakologija, Data status prevod sa Engleskog, urednik Prof. dr Zoran Todorović. (Original title)
      2. 2. Varagić M.V., Milošević P.M. (2010) Farmakologija, Elit Medica, Beograd. (Original title)
      Number of hours per week during the semester/trimester/year
      LecturesExercisesOTCStudy and ResearchOther classes
      Methods of teachingLecturing; preparation of seminar and public presentation of the experimetal work.
      Knowledge score (maximum points 100)
      Pre obligationsPointsFinal examPoints
      Activites during lectures10Test paper70
      Practical lessonsOral examination